Identifying Network Motifs that Buffer Front-to-Back Signaling in Polarized Neutrophils
Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges.Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa.However, analysis of cell-to-cell variation in human 9x11 pergola neutrophils revealed that back polarity remains consist